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Mimicking the human smell sensing mechanism with an artificial nose platform

Paper ID Volume ID Publish Year Pages File Format Full-Text
7155 537 2012 8 PDF Available
Title
Mimicking the human smell sensing mechanism with an artificial nose platform
Abstract

Sensing smell is a highly complex biological process, and characterizing and mimicking the interaction between the olfactory receptor (OR) protein and its ligands is extremely challenging. Herein, we report a highly sensitive and selective human nose-like nanobioelectronic nose (nbe-nose), which responds to gaseous odorants sensitively and selectively, has a signal specificity pattern similar to that in the cellular signal transduction pathway, and maintains an antagonistic behavior similar to the human nose. The human olfaction mechanism was mimicked by using carboxylated polypyrrole nanotubes (CPNTs) functionalized with human OR protein. The nbe-nose was able to detect gaseous odorants at a concentration as low as 0.02 parts-per-trillion (ppt), which was comparable to a highly trained, human expert’s nose. The nbe-nose can be used scientifically for smell mechanism studies. It can be also applied to various fields that rely on smell monitoring for industrial and public purposes.

Keywords
Nanobioelectronic nose; Human olfactory receptor; Conducting polymer nanotube; Antagonism
First Page Preview
Mimicking the human smell sensing mechanism with an artificial nose platform
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 6, February 2012, Pages 1722–1729
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering