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A novel approach for blood purification: Mixed-matrix membranes combining diffusion and adsorption in one step

Paper ID Volume ID Publish Year Pages File Format Full-Text
716 60 2012 9 PDF Available
Title
A novel approach for blood purification: Mixed-matrix membranes combining diffusion and adsorption in one step
Abstract

Hemodialysis is a commonly used blood purification technique in patients requiring kidney replacement therapy. Sorbents could increase uremic retention solute removal efficiency but, because of poor biocompatibility, their use is often limited to the treatment of patients with acute poisoning. This paper proposes a novel membrane concept for combining diffusion and adsorption of uremic retention solutes in one step: the so-called mixed-matrix membrane (MMM). In this concept, adsorptive particles are incorporated in a macro-porous membrane layer whereas an extra particle-free membrane layer is introduced on the blood-contacting side of the membrane to improve hemocompatibility and prevent particle release. These dual-layer mixed-matrix membranes have high clean-water permeance and high creatinine adsorption from creatinine model solutions. In human plasma, the removal of creatinine and of the protein-bound solute para-aminohippuric acid (PAH) by single and dual-layer membranes is in agreement with the removal achieved by the activated carbon particles alone, showing that under these experimental conditions the accessibility of the particles in the MMM is excellent. This study proves that the combination of diffusion and adsorption in a single step is possible and paves the way for the development of more efficient blood purification devices, excellently combining the advantages of both techniques.

Graphical abstractConcept of a dual layer mixed matrix membrane for blood purification, combining diffusion and adsorption in one step.Figure optionsDownload full-size imageDownload high-quality image (165 K)Download as PowerPoint slide

Keywords
Mixed-matrix membranes (MMM); Activated carbon; Creatinine; Adsorption; Blood purification
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A novel approach for blood purification: Mixed-matrix membranes combining diffusion and adsorption in one step
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 6, July 2012, Pages 2279–2287
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us