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The effect of collagen-binding vascular endothelial growth factor on the remodeling of scarred rat uterus following full-thickness injury

Paper ID Volume ID Publish Year Pages File Format Full-Text
7163 537 2012 7 PDF Available
Title
The effect of collagen-binding vascular endothelial growth factor on the remodeling of scarred rat uterus following full-thickness injury
Abstract

Serious injuries of uterine which lead to scar formation will finally result in infertility or pregnancy complications. There are few effective methods to treat such damages because of the shortage of native tissues. Vascular endothelial growth factor (VEGF) is important for the formation of new vessels and re-epithelialization of endometrium. Here we produced a collagen-binding VEGF by fusing a collagen-binding domain to the N-terminal of native VEGF. After injection into a rat scarred uterus model (partial of rat uterine horn was excised and left for scar formation) the collagen targeting VEGF promoted remodeling of the scarred uterus including the regeneration of endometrium, muscular cells, and vascularization and improved pregnancy outcomes. Thus, collagen-binding VEGF may be a pragmatic solution for the treatment of severe uterine damages.

Keywords
Vascular endothelial growth factor; Collagen-binding domain; Uterine horn scar regeneration; Tissue engineering
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The effect of collagen-binding vascular endothelial growth factor on the remodeling of scarred rat uterus following full-thickness injury
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 6, February 2012, Pages 1801–1807
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us