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Electrostatic charge conversion processes in engineered tumor-identifying polypeptides for targeted chemotherapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
7171 537 2012 10 PDF Available
Title
Electrostatic charge conversion processes in engineered tumor-identifying polypeptides for targeted chemotherapy
Abstract

One of the current challenges in cancer chemotherapy is the ultra-sensitive identification of in vivo tumors. Herein, we report a new class of tumor-identifying polypeptides that can home in on in vivo tumors via an electrostatic charge conversion process occurring in the acidic milieu of a verity of tumors, which can be distinguished from receptor-interacting conventional tumor-homing peptides. We exploit the chemical coupling between polypeptides and therapeutic objects (drugs or particles) to carry out an antitumor study in nude mice, and find a significant increase in the efficiency of polypeptide-tagged objects in tumor uptake and inhibition, which is more significant than any known tumor-homing peptide system thus far developed.

Keywords
Tumor-identifying polypeptide; Cancer chemotherapy; Tumor extracellular pH; Photodynamic therapy
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Electrostatic charge conversion processes in engineered tumor-identifying polypeptides for targeted chemotherapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 6, February 2012, Pages 1884–1893
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us