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The ROS scavenging and renal protective effects of pH-responsive nitroxide radical-containing nanoparticles

Paper ID Volume ID Publish Year Pages File Format Full-Text
7207 540 2011 8 PDF Available
Title
The ROS scavenging and renal protective effects of pH-responsive nitroxide radical-containing nanoparticles
Abstract

The ultimate objective of nanoparticle-based therapy is to functionalize nanomedicines in a micro-disease environment without any side effects. Here, we reveal that our pH-responsive nitroxide radical-containing nanoparticles (RNPpH) disintegrate within the renal acidic lesion and act as scavengers of reactive oxygen species (ROS), leading to a relief of acute kidney injury (AKI). RNPpH was prepared using amphiphilic block copolymers possessing 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) moieties via amine linkage as a side chain of the hydrophobic segment. The self-assembled RNPpH disintegrated at pH below 7.0 because of a protonation of the amino groups in the hydrophobic core of the nanoparticles, thereby resulting in an improvement in ROS scavenging activity. Using a renal ischemia-reperfusion AKI model in mice, the therapeutic effect of RNPpH on ROS damage was evaluated. Unlike the RNP without pH-triggered disintegration (RNPNon−pH), the RNPpH showed extremely high ROS scavenging activity and renal protective effects. It is interesting to note that the side effect of nitroxide radicals was markedly suppressed due to the compartmentalization of nitroxide radicals in the core of RNPpH in untargeted area. The morphology changes in RNPpH were confirmed by analyzing electron spin resonance spectra, and these findings provide the evidence of the real therapeutic effect of the environment-sensitive specific disintegration of nanoparticles in vivo.

Keywords
pH-responsive nanoparticle; Nitroxide radical; Ischemia-reperfusion; Antioxidant; Reactive oxygen species (ROS)
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The ROS scavenging and renal protective effects of pH-responsive nitroxide radical-containing nanoparticles
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 31, November 2011, Pages 8021–8028
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us