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Single nonfouling hydrogels with mechanical and chemical functionality gradients

Paper ID Volume ID Publish Year Pages File Format Full-Text
7237 542 2011 6 PDF Available
Title
Single nonfouling hydrogels with mechanical and chemical functionality gradients
Abstract

Hydrogels are widely studied as tissue engineering scaffolds, but the biological tissues they are designed to mimic are often complex tissues with non-uniform chemical and mechanical profiles. This work reports a new strategy to create hydrogels composed of a continuous sheet of a single nonfouling but functionalizable material with mechanical and/or chemical functionality gradients. By using different combinations of functionalizable or nonfunctionalizable versions of nonfouling carboxybetaine methacrylate (CBMA) and carboxybetaine dimethacrylate crosslinker (CBMAX), various hydrogels with gradients of crosslinking densities and/or functionalizable groups can be created. In this work, we demonstrate this concept with two nonfouling hydrogels, both with a mechanical gradient: one with uniform functionalizability and the other with a gradient in chemical functionalizability. With this versatile system, hydrogels with built-in gradient profiles of various types can be controlled at will for a given application.

Keywords
Hydrogel; Mechanical properties; Crosslinking; Ligament replacement
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Single nonfouling hydrogels with mechanical and chemical functionality gradients
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 33, November 2011, Pages 8456–8461
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us