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Vitamin E TPGS as a molecular biomaterial for drug delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
7280 543 2012 18 PDF Available
Title
Vitamin E TPGS as a molecular biomaterial for drug delivery
Abstract

d-α-tocopheryl polyethylene glycol succinate (Vitamin E TPGS, or simply TPGS) is a water-soluble derivative of natural Vitamin E, which is formed by esterification of Vitamin E succinate with polyethylene glycol (PEG). As such, it has advantages of PEG and Vitamin E in application of various nanocarriers for drug delivery,  including extending the half-life of the drug in plasma and enhancing the cellular uptake of the drug. TPGS has an amphiphilic structure of lipophilic alkyl tail and hydrophilic polar head with a hydrophile/lipophile balance (HLB) value of 13.2 and a relatively low critical micelle concentration (CMC) of 0.02% w/w, which make it to be an ideal molecular biomaterial in developing various drug delivery systems, including prodrugs, micelles, liposomes and nanoparticles, which would be able to realize sustained, controlled and targeted drug delivery as well as to overcome multidrug resistance (MDR) and to promote oral drug delivery as an inhibitor of P-glycoprotein (P-gp). In this review, we briefly discuss its physicochemical and pharmaceutical properties and its wide applications in composition of the various nanocarriers for drug delivery, which we call TPGS-based drug delivery systems.

Keywords
Cancer nanotechnology; Biodegradable polymers; Liposomes; Micelles; Nanoparticles; Prodrugs
First Page Preview
Vitamin E TPGS as a molecular biomaterial for drug delivery
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 19, June 2012, Pages 4889–4906
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering