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Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype

Paper ID Volume ID Publish Year Pages File Format Full-Text
7286 543 2012 8 PDF Available
Title
Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype
Abstract

Particulate vaccines are emerging promising technologies for the creation of tunable prophylactics against a wide variety of conditions. Vesicular and solid biodegradable polymer platforms, exemplified by liposomes and polyesters, respectively, are two of the most ubiquitous platforms in vaccine delivery studies. Here we directly compared the efficacy of each in a long-term immunization study and in protection against a model bacterial antigen. Immunization with poly(lactide-co-glycolide) (PLGA) nanoparticles elicited prolonged antibody titers compared to liposomes and alum. The magnitude of the cellular immune response was also highest in mice vaccinated with PLGA, which also showed a higher frequency of effector-like memory T cell phenotype, leading to an effective clearance of intracellular bacteria. The difference in performance of these two common particulate platforms is shown not to be due to material differences but appears to be connected to the kinetics of antigen delivery. Thus, this study highlights the importance of sustained antigen release mediated by particulate platforms and its role in the long-term appearance of effector memory cellular response.

Keywords
Liposome; PLGA; Nanoparticle; Persistence; Vaccine; Memory T cellsPLGA, poly (lactic co-glycolic acid); TLR, Toll-like receptor; OVA, Ovalbumin; LM-OVA, Listeria monocytogenes-OVA construct
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Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 19, June 2012, Pages 4957–4964
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us