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Internalization of C60 fullerenes into cancer cells with accumulation in the nucleus via the nuclear pore complex

Paper ID Volume ID Publish Year Pages File Format Full-Text
7323 548 2012 9 PDF Available
Title
Internalization of C60 fullerenes into cancer cells with accumulation in the nucleus via the nuclear pore complex
Abstract

A highly water-soluble, non-ionic, and non-cytotoxic fullerene malonodiserinolamide-derivatized fullerene C60 (C60-ser) is under investigation as a potential nanovector to deliver biologic and cancer drugs across biological barriers. Using laser-scanning confocal microscopy and flow cytometry, we find that PF-633 fluorophore conjugated C60-ser nanoparticles (C60-serPF) are internalized within living cancer cells in association with serum proteins through multiple energy-dependent pathways, and escape endocytotic vesicles to eventually localize and accumulate in the nucleus of the cells through the nuclear pore complex. Furthermore, in a mouse model of liver cancer, the C60-serPF conjugate is detected in most tissues, permeating through the altered vasculature of the tumor and the tightly-regulated blood brain barrier while evading the reticulo-endothelial system.

Keywords
Fullerenes; Nucleus; Cancer; Liver; Nuclear pore complex; Biodistribution
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Internalization of C60 fullerenes into cancer cells with accumulation in the nucleus via the nuclear pore complex
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 10, April 2012, Pages 2952–2960
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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