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Magnetite-loaded fluorine-containing polymeric micelles for magnetic resonance imaging and drug delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
7329 548 2012 12 PDF Available
Title
Magnetite-loaded fluorine-containing polymeric micelles for magnetic resonance imaging and drug delivery
Abstract

Magnetite (Fe3O4) – loaded polymer micelles (denoted as “magnetomicelles”) are produced by self-assembly of fluorine-containing amphiphilic poly(HFMA-g-PEGMA) copolymers with oleic acid modified Fe3O4 nanoparticles in an aqueous medium. The oleic acid modified Fe3O4 nanoparticles form small clusters in the poly(HFMA-g-PEGMA) micelles with a mean diameter of 100 nm and the magnetomicelles show high stability in an aqueous medium due to the high hydrophobic fluorine segments in graft copolymers enhance the stability of the micelles. The magnetomicelles also show good cytocompatibility based on the MTT cytotoxicity assay and possess paramagnetic properties with saturation magnetization of 17.14 emu/g.Their good stability, cytocompatibility, and paramagnetic properties render the materials attractive in drug delivery and in vivo magnetic resonance imaging (MRI) applications. Controlled release of hydrophobic drug-5-fluorouracil is achieved from the magnetomicelles with a loading efficiency of 20.94 wt%. The magnetomicelles have transverse relaxivity rates (r2) of 134.27 mM−1 s−1 and exhibit high efficacy as a negative MRI agent in T2-weighted imaging. In vivo MRI studies demonstrate that the contrast between liver and spleen is enhanced by the magnetomicelles. These favorable properties suggest clinical use as nanocarriers in drug delivery applications and contrast agents in MRI.

Keywords
Copolymers; Fluorine-fluoride; Micelle; MRI; Drug delivery
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Magnetite-loaded fluorine-containing polymeric micelles for magnetic resonance imaging and drug delivery
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 10, April 2012, Pages 3013–3024
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us