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Chemically amplified photoresist for high resolution autoradiography in targeted radiotherapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
7388 551 2011 7 PDF Available
Title
Chemically amplified photoresist for high resolution autoradiography in targeted radiotherapy
Abstract

Evaluation of the intracellular distribution of radionuclides used for targeted radiotherapy (tRT) is essential for accurate dosimetry. Therefore, a direct and quantitative method for subcellular micro-autoradiography using radiation sensitive polymers (PMMA, UV1116 and AZ40XT) was developed. The electron exposure dose in radio-labelled cells due to Auger and internal conversion (IC) electron emissions of indium (111In), a radionuclide currently used for tRT, was calculated using Monte Carlo (MC) simulation. Electron beam lithography using pre-defined exposure doses was used to calibrate the resist response. The topography of the exposed and developed resists was analysed with atomic force microscopy (AFM) and the resulting pattern depth was related to a specific exposure dose. UV1116 exhibited the best contrast as compared to AZ40XT and PMMA, while AZ40XT exhibited the highest sensitivity at low doses (<10 μC/cm2). AFM analysis of the exposure pattern from radio-labelled cells and nuclei in UV1116 revealed a non-uniform distribution of 111In-EGF in the cell and nucleus, consistent with less well-resolved data from confocal microscopy and micro-autoradiography.

Keywords
Auger electrons; Targeted radiotherapy; Intracellular distribution; Microdosimetry; Chemically amplified photoresists
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Chemically amplified photoresist for high resolution autoradiography in targeted radiotherapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 26, September 2011, Pages 6138–6144
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us