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Ambidextrous magnetic nanovectors for synchronous gene transfection and labeling of human MSCs

Paper ID Volume ID Publish Year Pages File Format Full-Text
7392 551 2011 9 PDF Available
Title
Ambidextrous magnetic nanovectors for synchronous gene transfection and labeling of human MSCs
Abstract

The synchronization of gene expression and cell trafficking in transfected stem cells is crucial for augmentation of stem cell functions (differentiation and neurotropic factor secretion) and real time in vivo monitoring. We report a magnetic nanoparticle-based gene delivery system that can ensure simultaneous gene delivery and in vivo cell trafficking by high resolution MR imaging. The polar aprotic solvent soluble MnFe2O4 nanoparticles were enveloped using cationic polymers (branched polyethyleneimine, PEI) by the solvent shifting method for a gene loading. Using our magnetic nanovector system (PEI-coated MnFe2O4 nanoparticles), thus, we synchronized stem cell migration and its gene expression in a rat stroke model.

Keywords
Magnetic; Nanovectors; Gene delivery; Stem cell; Solvent shifting
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Ambidextrous magnetic nanovectors for synchronous gene transfection and labeling of human MSCs
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 26, September 2011, Pages 6174–6182
Authors
, , , , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us