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Magnetically-enabled and MR-monitored selective brain tumor protein delivery in rats via magnetic nanocarriers

Paper ID Volume ID Publish Year Pages File Format Full-Text
7399 551 2011 9 PDF Available
Title
Magnetically-enabled and MR-monitored selective brain tumor protein delivery in rats via magnetic nanocarriers
Abstract

The delivery of bioactive proteins to tumors is associated with many difficulties that have impeded clinical translation of these promising therapeutics. Herein we present an approach, including (1) use of magnetically-responsive and MRI-visible nanoparticles as drug carriers, (2) topography-optimized intra-arterial magnetic targeting, (3) MRI-guided subject alignment within the magnetic field, and (4) surface modification of the protein drug with membrane-permeable polyethyleneimine (PEI), to prevail over the obstacles in protein delivery. Applying these methodologies, we demonstrated the delivery of a significant quantity of β-Galactosidase selectively into brain tumors of glioma-bearing rats, while limiting the exposure of normal brain regions. Clinical viability of the technologies utilized, and the ability to deliver proteins at high nanomolar-range tumor concentrations, sufficient to completely eradicate a tumor lesion with existing picomolar-potency protein toxins, renders the prospect of enabling protein-based cancer therapy extremely promising.

Keywords
Drug delivery; Protein delivery; Magnetic nanoparticles; Magnetic targeting; MR imaging; Brain tumor targeting
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Magnetically-enabled and MR-monitored selective brain tumor protein delivery in rats via magnetic nanocarriers
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 26, September 2011, Pages 6245–6253
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us