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The beneficial effects of deferred delivery on the efficiency of hydrogel therapy post myocardial infarction

Paper ID Volume ID Publish Year Pages File Format Full-Text
7445 553 2012 7 PDF Available
Title
The beneficial effects of deferred delivery on the efficiency of hydrogel therapy post myocardial infarction
Abstract

Biomaterials are increasingly being investigated as a means of reducing stress within the ventricular wall of infarcted hearts and thus attenuating pathological remodelling and loss of function. In this context, we have examined the influence of timing of delivery on the efficacy of a polyethylene glycol hydrogel polymerised with an enzymatically degradable peptide sequence. Delivery of the hydrogel immediately after infarct induction resulted in no observable improvements, but a delay of one week in delivery resulted in significant increases in scar thickness and fractional shortening, as well as reduction in end-systolic diameter against saline controls and immediately injected hydrogel at both 2 and 4 weeks post-infarction (p < 0.05). Hydrogels injected at one week were degraded significantly slower than those injected immediately and this may have played a role in the differing outcomes. The hydrogel assumed markedly different morphologies at the two time points having either a fibrillar or bulky appearance after injection immediately or one week post-infarction respectively. We argue that the different morphologies result from infarction induced changes in the cardiac structure and influence the degradability of the injectates. The results indicate that timing of delivery is important and that very early time points may not be beneficial.

Keywords
Heart; Hydrogel; Infarction; Remodelling
First Page Preview
The beneficial effects of deferred delivery on the efficiency of hydrogel therapy post myocardial infarction
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 7, March 2012, Pages 2060–2066
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering