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Off-resonance plasmonic enhanced femtosecond laser optoporation and transfection of cancer cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
7475 553 2012 6 PDF Available
Title
Off-resonance plasmonic enhanced femtosecond laser optoporation and transfection of cancer cells
Abstract

A femtosecond laser based transfection method using off-resonance plasmonic gold nanoparticles is described. For human cancer melanoma cells, the treatment leads to a very high perforation rate of 70%, transfection efficiency three times higher than for conventional lipofection, and very low toxicity (<1%). Off-resonance laser excitation inhibited the fracture of the nanoparticles into possibly toxic DNA intercalating particles. This efficient and low toxicity method is a promising alternative to viral transfection for skin cancer treatment.

Keywords
Optoperforation; Transfection; Gold nanoparticle; Plasmonic; Femtosecond laser; Cancer cell
First Page Preview
Off-resonance plasmonic enhanced femtosecond laser optoporation and transfection of cancer cells
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 7, March 2012, Pages 2345–2350
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering