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A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
7510 554 2011 13 PDF Available
Title
A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery
Abstract

Success in the oral delivery of therapeutic insulin can significantly improve the quality of life of diabetic patients who must routinely receive injections of this drug. However, oral absorption of insulin is limited by various physiological barriers and remains a major scientific challenge. Various technological solutions have been developed to increase the oral bioavailability of insulin. Having received considerable attention, nano-sized polymeric particles are highly promising for oral insulin delivery. This review article describes the gastrointestinal barriers to oral insulin delivery, including chemical, enzymatic and absorption barriers. The potential transport mechanisms of insulin delivered by nanoparticles across the intestinal epithelium are also discussed. Finally, recent advances in using polymeric nanoparticles for oral insulin delivery and their effects on insulin transport are reviewed, along with their future.

Keywords
Bioavailability; Transcellular pathway; Paracellular pathway; Target delivery; Formulation technology
First Page Preview
A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 36, December 2011, Pages 9826–9838
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering