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Design of interior-functionalized fully acetylated dendrimers for anticancer drug delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
7521 554 2011 10 PDF Available
Title
Design of interior-functionalized fully acetylated dendrimers for anticancer drug delivery
Abstract

In this study, dendrimers was synthesized by introducing functional groups into the interior pockets of fully acetylated dendrimers. NMR techniques including COSY and 2D-NOESY revealed the molecular structures of the synthesized dendrimers and the encapsulation of guest molecule such as methotrexate within their interior pockets. The synthesized polymeric nanocarriers showed much lower cytotoxicity on two cell lines than cationic dendrimers, and exhibited better performance than fully acetylated dendrimers in the sustained release of methotrexate. The results provided a new strategy in the design of non-toxic dendrimers with high performance in the delivery of anti-cancer drugs for clinical applications.

Keywords
Dendrimer; Interior-functionalized; Non-toxic; Acetylation; NMR
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Design of interior-functionalized fully acetylated dendrimers for anticancer drug delivery
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 36, December 2011, Pages 9950–9959
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us