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Bio-functionalisation of polydimethylsiloxane with hyaluronic acid and hyaluronic acid – Collagen conjugate for neural interfacing

Paper ID Volume ID Publish Year Pages File Format Full-Text
7542 556 2011 11 PDF Available
Title
Bio-functionalisation of polydimethylsiloxane with hyaluronic acid and hyaluronic acid – Collagen conjugate for neural interfacing
Abstract

In this work, polydimethylsiloxane was activated with oxygen plasma and treated with silanes bearing ethylene imine units. Hyaluronic acid was then grafted covalently onto the aminated surfaces. The influence of silane structure on surface amination was assessed and the influence of the modification on surface physiochemical properties and protein adsorption of modified polydimethylsiloxane were investigated. Collagen type I was conjugated onto the modified polydimethylsiloxane to improve its cyto-compatibility for neural applications. In vitro cultivation of rat pheochromocytoma cells on the bioactive polydimethylsiloxane showed a significant increase in cell growth and differentiation. The potential applications of the bio-functionalized polydimethylsiloxane in cochlear implant electrode arrays were discussed.

Keywords
Polydimethylsiloxane; Surface modification; Hyaluronic acid; Neural cells; Differentiation; Neural prosthesis
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Bio-functionalisation of polydimethylsiloxane with hyaluronic acid and hyaluronic acid – Collagen conjugate for neural interfacing
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 21, July 2011, Pages 4714–4724
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us