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The use of a library of industrial materials to determine the nature of substrate-dependent performance of primary adherent human cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
7602 558 2012 12 PDF Available
Title
The use of a library of industrial materials to determine the nature of substrate-dependent performance of primary adherent human cells
Abstract

We developed a library of industrial materials, which can be applied to any adherent cell type for determining cell–material interactions. Bulk and surface chemistry as well as other material properties were characterized. The library covered broad ranges of various material properties. We applied the library to primary human endothelial and epithelial cells, which play important roles in tissue engineering and biomedical applications. The results revealed that substrate stiffness was the major determinant of cell performance. The ability to grow and differentiate on stiff or more compliant materials was cell type-dependent, but cell performance was consistently best on stiff and smooth materials. These results give new insights into the nature of substrate-dependent performance of primary human cells and are potentially useful for the development of improved biomaterials. The materials of the library can be easily accessed by the scientific community to determine cell–material interactions of any adherent cell type of interest.

Keywords
Compliance; Hydrophilicity; Membrane; Cell proliferation; Epithelial cell; Endothelial cell
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The use of a library of industrial materials to determine the nature of substrate-dependent performance of primary adherent human cells
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 2, January 2012, Pages 353–364
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us