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Exploiting extracellular matrix-stem cell interactions: A review of natural materials for therapeutic muscle regeneration

Paper ID Volume ID Publish Year Pages File Format Full-Text
7609 558 2012 16 PDF Available
Title
Exploiting extracellular matrix-stem cell interactions: A review of natural materials for therapeutic muscle regeneration
Abstract

Myopathies of skeletal muscle are prevalent diseases worldwide. To address this, regenerative therapies are being developed to restore perfusion to ischemic muscle and to reverse muscle wasting. There are adult stem cell populations that inherently possess these therapeutic properties; however, cell transplantation trials in the clinic have shown modest results at best, being limited by poor cell persistence and viability post-transplantation, and by cell relocation to non-target sites. Many materials exist that can elicit and enhance beneficial cell responses – these materials can be applied directly, or used as stem cell delivery vehicles, for regenerative therapies. In particular, components of the body’s extracellular matrices may be advantageous for therapeutic application because cells already have a pre-disposition for recognizing them, and also because their usage carries a low probability of inducing negative immune responses. This review will survey the major components of the extracellular matrix and their interactions with relevant stem cell populations for the regeneration of muscle. Future material-based therapies will benefit from a more precise control over therapeutic cell populations implicated in the regenerative response.

Keywords
Angiogenesis; Extracellular matrix; Muscle; Stem cell
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Exploiting extracellular matrix-stem cell interactions: A review of natural materials for therapeutic muscle regeneration
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 2, January 2012, Pages 428–443
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us