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Gold nanoparticle-incorporated human red blood cells (RBCs) for X-ray dynamic imaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
7670 559 2011 9 PDF Available
Title
Gold nanoparticle-incorporated human red blood cells (RBCs) for X-ray dynamic imaging
Abstract

Time-resolved dynamic imaging of bio-fluids can provide valuable information for clinical diagnosis and treatment of circulatory disorders. Quantitative information on non-transparent blood flows can be directly obtained by particle-tracing dynamic X-ray imaging, which needs better spatial resolution and enhanced image contrast compared to static imaging. For that use, tracer particles tagging along the flow streams are critically required. In this study, taking the advantage of high X-ray absorption, gold nanoparticles (AuNPs) are incorporated into human red blood cells (RBC) to produce contrast-enhanced tracers designed for dynamic X-ray imaging of blood flows. RBCs are advantageous tracers for blood flow measurements since they are natural and primary components of blood. The loading efficiency of AuNPs into RBCs is investigated in terms of the surface properties of the AuNPs. The AuNP-incorporated RBC provides a potential in the dynamic X-ray imaging of blood flows which can be used for clinical applications.

Keywords
Gold nanoparticles; Red blood cells; Flow tracer; Dynamic X-ray imaging
First Page Preview
Gold nanoparticle-incorporated human red blood cells (RBCs) for X-ray dynamic imaging
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 29, October 2011, Pages 7191–7199
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering