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Core–shell NaYF4:Yb3+,Tm3+@FexOy nanocrystals for dual-modality T2-enhanced magnetic resonance and NIR-to-NIR upconversion luminescent imaging of small-animal lymphatic node

Paper ID Volume ID Publish Year Pages File Format Full-Text
7671 559 2011 9 PDF Available
Title
Core–shell NaYF4:Yb3+,Tm3+@FexOy nanocrystals for dual-modality T2-enhanced magnetic resonance and NIR-to-NIR upconversion luminescent imaging of small-animal lymphatic node
Abstract

New core–shell structured NaYF4:Yb3+,Tm3+@FexOy nanocrystals, with 20 nm Yb3+,Tm3+-co-doped NaYF4 nanocrystals as a core and 5 nm FexOy nanocrystals as a shell, have been synthesized and characterized by TEM and XRD analysis. These core–shell nanocrystals exhibit excellent near-infrared upconversion luminescence (UCL) emission at 800 nm under excitation by a continuous-wave 980 nm laser and superparamagnetic properties with a saturation magnetization (Ms) of ∼12 emu/g. Water-soluble nanocrystals were obtained by surface ligand exchange of oleic acid-coated precursor nanocrystals, and their internalization within living cells has been investigated by laser scanning UCL microscopy. Furthermore, the obtained core–shell nanocrystals have been applied in dual-modality T2-enhanced magnetic resonance (MR) and UCL imaging in vivo of the lymphatic system. Moreover, the toxicity of NaYF4:Yb3+,Tm3+@FexOy nanocrystals has also been evaluated by MTT assay, IC50 values, and histological analysis of lymphatic node sections.

Keywords
Core-shell nanocrystals; Upconversion luminescence; Magnetic resonance imaging; Multimodality imaging
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Core–shell NaYF4:Yb3+,Tm3+@FexOy nanocrystals for dual-modality T2-enhanced magnetic resonance and NIR-to-NIR upconversion luminescent imaging of small-animal lymphatic node
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 29, October 2011, Pages 7200–7208
Authors
, , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us