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Multifunctional and degradable zwitterionic nanogels for targeted delivery, enhanced MR imaging, reduction-sensitive drug release, and renal clearance

Paper ID Volume ID Publish Year Pages File Format Full-Text
7693 560 2011 5 PDF Available
Title
Multifunctional and degradable zwitterionic nanogels for targeted delivery, enhanced MR imaging, reduction-sensitive drug release, and renal clearance
Abstract

Multifunctional and degradable nanogels encapsulating both model drug (fluorescently labeled dextran) and imaging reagent (monodisperse Fe3O4 nanoparticles) were developed by polymerizing zwitterionic monomers with a disulfide crosslinker. Results show that the nanogels have a hydrodynamic size of about 110 nm in saline solution and their size remained unchanged for over 6 months. After being conjugated with a targeting ligand, the nanogels showed a significant cellular uptake by human umbilical vein endothelial cells (HUVEC). The nanogels show low macrophage uptake, implying potential low interaction with the innate immune system. Upon entering the reducing intracellular environment, the disulfide bonds were efficiently cleaved, resulting in the spontaneous release of the encapsulated model drug and Fe3O4 nanoparticles. Magnetic resonance imaging (MRI) studies show that the encapsulation of multiple monodisperse Fe3O4 nanoparticles by the nanogels significantly enhanced their MRI performance (R2 relaxivity), while the disassembling of the Fe3O4 nanoparticles due to the nanogels degradation brings their R2 relaxivity back to that of their original monodisperse form. Furthermore, the degradation properties enable the removal of the disassembled nanogels from the body by renal clearance.

Keywords
Zwitterionic; Degradable; Reduction-sensitive; Renal clearance; Targeting; MRI (magnetic resonance imaging)
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Multifunctional and degradable zwitterionic nanogels for targeted delivery, enhanced MR imaging, reduction-sensitive drug release, and renal clearance
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 20, July 2011, Pages 4604–4608
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us