fulltext.study @t Gmail

The modulation of platelet adhesion and activation by chitosan through plasma and extracellular matrix proteins

Paper ID Volume ID Publish Year Pages File Format Full-Text
7783 564 2011 8 PDF Available
Title
The modulation of platelet adhesion and activation by chitosan through plasma and extracellular matrix proteins
Abstract

Chitosan has been shown to promote initial wound closure events to prevent blood loss. Platelet adhesion and activation are crucial early events in these processes after traumatic bleeding leading to thrombus formation. Platelet adhesion to chitosan was found to be enhanced in the presence of adsorbed plasma and extracellular matrix proteins and was found to be primarily mediated by αIIbβ3 integrins, while α2β1 integrins were found to be involved in platelet adhesion to collagen and perlecan. Platelets were found to be activated by chitosan, as shown by an increase in the expression of αIIbβ3 integrins and P-selectin, while the extent of activation was modulated by the presence of proteins including perlecan and fibrinogen. Collagen-coated chitosan was found to activate platelets to the same extent as either chitosan or collagen alone. These data support the role of plasma and extracellular matrix proteins in promoting chitosan mediated platelet adhesion and activation supporting the hypothesis that chitosan promotes wound healing via these interactions.

► We investigated platelet adhesion to chitosan pre-adsorbed with plasma or extracellular matrix proteins. ► Platelet adhesion to chitosan was enhanced in the presence of adsorbed plasma and extracellular matrix proteins. ► Platelets bound to perlecan coated chitosan through integrin α2β1. ► Chitosan activated platelets, while the extent of activation was modulated by the presence of proteins.

Keywords
Chitosan; Platelets; Integrins; Protein adsorption
First Page Preview
The modulation of platelet adhesion and activation by chitosan through plasma and extracellular matrix proteins
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 28, October 2011, Pages 6655–6662
Authors
, , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us