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Immune responses to implants – A review of the implications for the design of immunomodulatory biomaterials

Paper ID Volume ID Publish Year Pages File Format Full-Text
7788 564 2011 18 PDF Available
Title
Immune responses to implants – A review of the implications for the design of immunomodulatory biomaterials
Abstract

A key for long-term survival and function of biomaterials is that they do not elicit a detrimental immune response. As biomaterials can have profound impacts on the host immune response the concept emerged to design biomaterials that are able to trigger desired immunological outcomes and thus support the healing process. However, engineering such biomaterials requires an in-depth understanding of the host inflammatory and wound healing response to implanted materials.One focus of this review is to outline the up-to-date knowledge on immune responses to biomaterials. Understanding the complex interactions of host response and material implants reveals the need for and also the potential of “immunomodulating” biomaterials. Based on this knowledge, we discuss strategies of triggering appropriate immune responses by functional biomaterials and highlight recent approaches of biomaterials that mimic the physiological extracellular matrix and modify cellular immune responses.

Keywords
Immune response to biomaterials; Immunomodulation; Extracellular matrix; Biomaterial integrationaECM, artificial ECM; BMP, bone morphogenetic protein; CCL, CC chemokine ligand; COX-2, cyclooxygenase-2; CS, chondroitin sulfate; CXCL, CXC chemokine ligand;
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Immune responses to implants – A review of the implications for the design of immunomodulatory biomaterials
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 28, October 2011, Pages 6692–6709
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us