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Phosphate glass fibres and their role in neuronal polarization and axonal growth direction

Paper ID Volume ID Publish Year Pages File Format Full-Text
782 63 2012 12 PDF Available
Title
Phosphate glass fibres and their role in neuronal polarization and axonal growth direction
Abstract

Phosphate glass fibres with composition 50P2O5–30CaO–9Na2O–3SiO2–3MgO–(5 − x)K2O–xTiO2 mol.% (x = 0, 2.5, 5, respectively coded as TiPS0, TiPS2.5 and TiPS5) were drawn following the preform drawing approach. A 20-day solubility test in bi-distilled water was carried out on glass fibres with different compositions and diameters ranging between 25 and 82 μm. The results show that the glass composition, the initial fibre diameter and the thermal treatment are the main factors influencing the dissolution kinetics and that the fibres maintain their structural integrity and composition during dissolution.Biological tests were carried out on aligned TiPS2.5 glass fibres using Neonatal Olfactory Bulb Ensheathing Cell Line (NOBEC) and Dorsal Root Ganglia (DRG) neurons. The fibres showed to be permissive substrates for cell adhesion and proliferation. The aligned configuration of the fibres seemed to provide a directional cue for growing axons of DRG neurons, which showed to sprout and grow long neurites along the fibre axis direction.These promising findings encourages further studies to evaluate the potential use of resorbable glass fibres (e.g.in combination with a nerve guidance tube) for the enhancement of the peripheral nerve healing with the role of supporting and guiding the cells involved in the nerve regeneration.

Keywords
Phosphate glass fibres; Neuron; Glial cell; In vitro test; Nerve regeneration
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 3, March 2012, Pages 1125–1136
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us