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The effect of a slow mode of BMP-2 delivery on the inflammatory response provoked by bone-defect-filling polymeric scaffolds

Paper ID Volume ID Publish Year Pages File Format Full-Text
7855 567 2010 9 PDF Available
Title
The effect of a slow mode of BMP-2 delivery on the inflammatory response provoked by bone-defect-filling polymeric scaffolds
Abstract

We investigated the inflammatory response to, and the osteoinductive efficacies of, four polymers (collagen, Ethisorb™, PLGA and Polyactive®) that bore either an adsorbed (fast-release kinetics) or a calcium-phosphate-coating-incorporated (slow-release kinetics) depot of BMP-2. Titanium-plate-supported discs of each polymer (n = 6 per group) were implanted at an ectopic (subcutaneous) ossification site in rats (n = 48). Five weeks later, they were retrieved for a histomorphometric analysis of the volumes of ectopic bone and foreign-body giant cells (a gauge of inflammatory reactivity), and the degree of polymer degradation. For each polymer, the osteoinductive efficacy of BMP-2 was higher when it was incorporated into a coating than when it was directly adsorbed onto the material. This mode of BMP-2 carriage was consistently associated with an attenuation of the inflammatory response. For coated materials, the volume density of foreign-body giant cells was inversely correlated with the volume density of bone (r2 = 0.96), and the volume density of bone was directly proportional to the surface-area density of the polymer (r2 = 0.97). Following coating degradation, other competitive factors, such as the biocompatibility and the biodegradability of the polymer itself, came into play.

Keywords
Biocompatibility; Calcium-phosphate coating; Controlled drug release; Foreign-body giant cells; Inflammation; Osteogenesis
First Page Preview
The effect of a slow mode of BMP-2 delivery on the inflammatory response provoked by bone-defect-filling polymeric scaffolds
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 29, October 2010, Pages 7485–7493
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering