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Silicon-stabilized α-tricalcium phosphate and its use in a calcium phosphate cement: Characterization and cell response

Paper ID Volume ID Publish Year Pages File Format Full-Text
787 63 2012 11 PDF Available
Title
Silicon-stabilized α-tricalcium phosphate and its use in a calcium phosphate cement: Characterization and cell response
Abstract

α-Tricalcium phosphate (α-TCP) is widely used as a reactant in calcium phosphate cements. This work aims at doping α-TCP with silicon with a twofold objective. On the one hand, to study the effect of Si addition on the stability and reactivity of this polymorph. On the other, to develop Si-doped cements and to evaluate the effect of Si on their in vitro cell response. For this purpose a calcium-deficient hydroxyapatite was sintered at 1250 °C with different amounts of silicon oxide. The high temperature polymorph α-TCP was stabilized by the presence of silicon, which inhibited reversion of the β → α transformation, whereas in the Si-free sample α-TCP completely reverted to the β-polymorph. However, the β–α transformation temperature was not affected by the presence of Si. Si–α-TCP and its Si-free counterpart were used as reactants for a calcium phosphate cement. While Si–α-TCP showed faster hydrolysis to calcium-deficient hydroxyapatite, upon complete reaction the crystalline phases, morphology and mechanical properties of both cements were similar. An in vitro cell culture study, in which osteoblast-like cells were exposed to the ions released by both materials, showed a delay in cell proliferation in both cases and stimulation of cell differentiation, more marked for the Si-containing cement. These results can be attributed to strong modification of the ionic concentrations in the culture medium by both materials. Ca-depletion from the medium was observed for both cements, whereas continuous Si release was detected for the Si-containing cement.

Keywords
Tricalcium phosphate; Silicon; Hydroxyapatite; Calcium phosphate cements; Cell response
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Silicon-stabilized α-tricalcium phosphate and its use in a calcium phosphate cement: Characterization and cell response
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 3, March 2012, Pages 1169–1179
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us