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Selective antileukemia effect of stabilized nanohybrid vesicles based on cholesteryl succinyl silane

Paper ID Volume ID Publish Year Pages File Format Full-Text
7883 568 2011 8 PDF Available
Title
Selective antileukemia effect of stabilized nanohybrid vesicles based on cholesteryl succinyl silane
Abstract

A nanohybrid vesicle was developed from cholesteryl succinyl silane(CSS) in combination of sol–gel process and self-assembly technique. The silicalike surface adds CSS vesicles remarkably high stability against destabilization in blood or leakage of drug cargos. It was found that CSS vesicles alone exhibited selective antiproliferative effects on leukemia cells without destroying normal blood cells. In addition, they are able to encapsulate not only hydrophilic guest species inside the inner water compartment but also hydrophobic molecules in the cholesteryl succinyl bilayer membrane. More importantly, CSS vesicles loaded with doxorubicin enhanced the anticancer efficiency of cancer therapeutics greatly while minimizing the use of inactive materials and lowering the exposure of normal cells to toxic side effects. This makes CSS vesicle a promising carrier for the treatment of cancer, especially for leukemia.

Keywords
Nanohybrid vesicles; Active carriers; Selective anticancer effects; Cholesteryl derivative; Leukemia cells
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Selective antileukemia effect of stabilized nanohybrid vesicles based on cholesteryl succinyl silane
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 35, December 2011, Pages 9300–9307
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us