fulltext.study @t Gmail

Preferential accumulation within tumors and in vivo imaging by functionalized luminescent dendrimer lanthanide complexes

Paper ID Volume ID Publish Year Pages File Format Full-Text
7887 568 2011 10 PDF Available
Title
Preferential accumulation within tumors and in vivo imaging by functionalized luminescent dendrimer lanthanide complexes
Abstract

We have created a dendrimer complex suitable for preferential accumulation within liver tumors and luminescence imaging by substituting thirty-two naphthalimide fluorophores on the surface of the dendrimer and incorporating eight europium cations within the branches. We demonstrate the utility and performance of this luminescent dendrimer complex to detect hepatic tumors generated via direct subcapsular implantation or via splenic injections of colorectal cancer cells (CC531) into WAG/RijHsd rats. Luminescence imaging of the tumors after injection of the dendrimer complex via hepatic arterial infusion revealed that the dendrimer complex can preferentially accumulate within liver tumors. Further investigation indicated that dendrimer luminescence in hepatic tumors persisted in vivo. Due to the incorporation of lanthanide cations, this luminescence agent presents a strong resistance against photobleaching. These studies show the dendrimer complex has great potential to serve as an innovative accumulation and imaging agent for the detection of metastatic tumors in our rat hepatic model.

Keywords
Animal model; Functionalized dendrimer; Luminescence imaging; Hepatic tumor; Hepatic arterial infusionCCD, charged coupled device; CE, capillary electrophoresis; CRC, colorectal cancer; CZE, capillary zone electrophoresis; DAPI, 4′,6-diamidino-2-phenylind
First Page Preview
Preferential accumulation within tumors and in vivo imaging by functionalized luminescent dendrimer lanthanide complexes
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 35, December 2011, Pages 9343–9352
Authors
, , , , , , , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us