fulltext.study @t Gmail

Magnesium alloys for temporary implants in osteosynthesis: In vivo studies of their degradation and interaction with bone

Paper ID Volume ID Publish Year Pages File Format Full-Text
793 63 2012 9 PDF Available
Title
Magnesium alloys for temporary implants in osteosynthesis: In vivo studies of their degradation and interaction with bone
Abstract

This study investigates the bone and tissue response to degrading magnesium pin implants in the growing rat skeleton by continuous in vivo microfocus computed tomography (μCT) monitoring over the entire pin degradation period, with special focus on bone remodeling after implant dissolution. The influence of gas release on tissue performance upon degradation of the magnesium implant is also addressed. Two different magnesium alloys – one fast degrading (ZX50) and one slowly degrading (WZ21) – were used for evaluating the bone response in 32 male Sprague–Dawley rats. After femoral pin implantation μCTs were performed every 4 weeks over the 24 weeks of the study period. ZX50 pins exhibited early degradation and released large hydrogen gas volumes. While considerable callus formation occurred, the bone function was not permanently harmed and the bone recovered unexpectedly quickly after complete pin degradation. WZ21 pins kept their integrity for more than 4 weeks and showed good osteoconductive properties by enhancing bone accumulation at the pin surface. Despite excessive gas formation, the magnesium pins did not harm bone regeneration. At smaller degradation rates, gas evolution remained unproblematic and the magnesium implants showed good biocompatibility. Online μCT monitoring is shown to be suitable for evaluating materials degradation and bone response in vivo, providing continuous information on the implant and tissue performance in the same living animal.

Keywords
Magnesium; Biodegradation; Growing rat skeleton; In vivo small animal imaging; Microfocus computed tomography (μCT)
First Page Preview
Magnesium alloys for temporary implants in osteosynthesis: In vivo studies of their degradation and interaction with bone
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 3, March 2012, Pages 1230–1238
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us