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Preparation of three-dimensional interconnected macroporous cellulosic hydrogels for soft tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
7934 570 2010 12 PDF Available
Title
Preparation of three-dimensional interconnected macroporous cellulosic hydrogels for soft tissue engineering
Abstract

This work exploits the thermal responsive phase behavior of hydroxypropylcellulose to produce 3D interconnected macroporous hydrogels in aqueous environment. Hydroxypropylcellulose was modified with allyl isocyanate, and their temperature mediated phase behavior was studied as a function of degree of modification (DS). A derivative with a DS of 1.5 was selected for scaffold preparation. Its aqueous solutions were warmed up to trigger the formation of biphasic systems. Such state was then immobilized efficiently by γ-ray irradiated crosslinking. Lyophilization of the crosslinked hydrogels yielded 3D macroporous sponges. The re-hydrated gels demonstrate a combination of interconnected macroporosity, high water content and mechanical integrity to soft tissues. Cytocompatibility was demonstrated among various cell types, and in vivo biocompatibility test showed minimal inflammatory response within 12 weeks’ subcutaneous implantation in mice. The potential applications of these macroporous hydrogels in tissue engineering are discussed.

Keywords
Hydrogels; Porous materials; Cellulose; Thermally responsive materials; Tissue Engineering
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Preparation of three-dimensional interconnected macroporous cellulosic hydrogels for soft tissue engineering
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 32, November 2010, Pages 8141–8152
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us