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Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors

Paper ID Volume ID Publish Year Pages File Format Full-Text
7960 570 2010 9 PDF Available
Title
Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors
Abstract

The prognosis of patients with malignant glioma remains extremely poor, despite surgery and improvements in radio- and chemo-therapies. Nanotechnologies represent great promise in glioma therapy as they protect therapeutic agent and allow its sustained release. However, new paradigms allowing tumor specific targeting and extensive intratumoral distribution must be developed to efficiently deliver nanoparticles (NPs). Knowing the tropism of mesenchymal stem cells (MSCs) for brain tumors, the aim of this study was to obtain the proof of concept that these cells can be used as NP delivery vehicles. Two types of NPs loaded with coumarin-6 were investigated: poly-lactic acid NPs (PLA-NPs) and lipid nanocapsules (LNCs). The results show that these NPs can be efficiently internalized into MSCs while cell viability and differentiation are not affected. Furthermore, these NP-loaded cells were able to migrate toward an experimental human glioma model. These data suggest that MSCs can serve as cellular carriers for NPs in brain tumors.

Keywords
Mesenchymal stem cells; Nanoparticles; Glioma; Cellular vehicle
First Page Preview
Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 32, November 2010, Pages 8393–8401
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering