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Photo-cured hyaluronic acid-based hydrogels containing simvastatin as a bone tissue regeneration scaffold

Paper ID Volume ID Publish Year Pages File Format Full-Text
8005 573 2011 11 PDF Available
Title
Photo-cured hyaluronic acid-based hydrogels containing simvastatin as a bone tissue regeneration scaffold
Abstract

We describe in this study the positive influences on in vitro and in vivo osteogenesis of photo-cured hyaluronic acid (HA) hydrogels loaded with simvastatin (SIM). Prior to loading SIM, we first characterized the HA hydrogels for their mechanical properties and swelling ratios. The results from this testing indicated that these two factors improved as the substitution degree of 2-aminoethyl methacrylate (AEMA) increased. MTT and live/dead assays showed that the HA hydrogels have good biocompatibility for use as scaffolds for bone tissue regeneration. Moreover, another MTT assay showed that the photo-cured HA hydrogels III fabricated with 30% AEMA (300 mg) conjugated HA (HA-AEMA iii) loaded with between 0.1 and 1 mg of SIM had a similar cytotoxicity as compared to the HA hydrogel III itself. The sustained release of SIM was observed to occur in the HA hydrogel III loaded with 1 mg of SIM. In vitro and in vivo experiments showed that the HA hydrogel III loaded with 1 mg of SIM had a significant influence on osteogenesis.

Keywords
Photopolymerization; Hyaluronic acid; Hydrogel; Simvastatin; Bone tissue regeneration
First Page Preview
Photo-cured hyaluronic acid-based hydrogels containing simvastatin as a bone tissue regeneration scaffold
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 32, November 2011, Pages 8161–8171
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering