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Poly(amidoamine) dendronized hollow fiber membranes: Synthesis, characterization, and preliminary applications as drug delivery devices

Paper ID Volume ID Publish Year Pages File Format Full-Text
802 63 2012 7 PDF Available
Title
Poly(amidoamine) dendronized hollow fiber membranes: Synthesis, characterization, and preliminary applications as drug delivery devices
Abstract

Poly(amidoamine) (PAMAM) dendrons were prepared from hollow fiber membranes (HFM) consisting of bromomethylated poly(2,6-dimethyl-1,4-phenylene oxide) (BPPO) in a stepwise manner. The prepared HFM were characterized by Fourier transform infrared spectroscopy, elemental analysis, and scanning electron microscopy. The drug loading efficiency and release behavior of the PAMAM dendronized HFM were evaluated using sodium salicylate, sodium methotrexate, and Congo red as model drugs. The results suggest that PAMAM dendronized HFM can be effectively loaded with a variety of drugs and prolong the release of these drugs. The drug loading and release characteristics of the HFM depend on the generation of PAMAM dendrons grafted on the membranes. The prepared PAMAM dendronized BPPO HFM are promising scaffolds in drug delivery and tissue engineering.

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Keywords
Hyperbranched; Dendrimer; Poly(amidoamine); Bromomethylated poly(2,6-dimethyl-1,4-phenylene oxide); Hollow fiber membrane
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 3, March 2012, Pages 1316–1322
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us