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Autologous extracellular matrix scaffolds for tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
8093 577 2011 11 PDF Available
Title
Autologous extracellular matrix scaffolds for tissue engineering
Abstract

Development of autologous scaffolds has been highly desired for implantation without eliciting adverse inflammatory and immune responses. However, it has been difficult to obtain autologous scaffolds by tissue decellularization because of the restricted availability of autologous donor tissues from a patient. Here we report a method to prepare autologous extracellular matrix (aECM) scaffolds by combining culture of autologous cells in a three-dimensional template, decellularization, and template removal. The aECM scaffolds showed excellent biocompatibility when implanted. We anticipate that “Full Autologous Tissue Engineering” can be realized to minimize undesirable host tissue responses by culturing the patient’s own cells in an aECM scaffold.

Keywords
Autologous extracellular matrix scaffold; Biomimetics; Tissue engineering; Decellularization
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Autologous extracellular matrix scaffolds for tissue engineering
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 10, April 2011, Pages 2489–2499
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us