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Self-activated luminescent and mesoporous strontium hydroxyapatite nanorods for drug delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
8143 578 2010 10 PDF Available
Title
Self-activated luminescent and mesoporous strontium hydroxyapatite nanorods for drug delivery
Abstract

Multifunctional strontium hydroxyapatite (SrHAp) nanorods with luminescent and mesoporous properties have been successfully synthesized by a hydrothermal method. SEM and TEM images indicate that the mesoporous SrHAp samples consist of monodiperse nanorods with lengths of 120–150 nm, diameters of around 20 nm, and the mesopore size of 3–5 nm. The as-obtained SrHAp nanorods show an intense bright blue emission (centered at 432 nm, lifetime 11.6 ns, quantum efficiency: 22%), which might arise from CO2·− radical impurities in the crystal lattice under long-wavelength UV-light irradiation. Furthermore, the amount of trisodium citrate has an obvious impact on the particle size and the luminescence properties of the products, respectively. The drug storage/release test indicates that the luminescent SrHAp nanorods show a drug loading and controlled release properties for ibuprofen (IBU). Additionally, the emission intensity of SrHAp in the drug carrier system increases with the cumulative released amount of IBU, making the drug release might be easily tracked and monitored by the change of the luminescence intensity. This luminescent material may be potentially applied in the drug delivery and disease therapy fields.

Keywords
Strontium hydroxyapatite; Nanorod; Luminescence; Mesoporous; Drug delivery
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 12, April 2010, Pages 3374–3383
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us