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Cell-laden microwells for the study of multicellularity in lymphocyte fate decisions

Paper ID Volume ID Publish Year Pages File Format Full-Text
8148 578 2010 7 PDF Available
Title
Cell-laden microwells for the study of multicellularity in lymphocyte fate decisions
Abstract

Cell–cell cooperativity in populations of motile and transiently interacting immune cells has been difficult to assess in the absence of tools to control proximity and communication. Here, we describe the generation of cell-laden microwells that can precisely control contact-mediated interactions and multicellular ‘quorum’ decisions in lymphocytes. Different types of fate decisions for activating T cells can be shown to variously obey ‘binary’ or ‘density’ outcomes, correlated with cell–cell contact, using this new platform.

Keywords
Hydrogel microwell; Multicellularity; T cell; Fate decision
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Cell-laden microwells for the study of multicellularity in lymphocyte fate decisions
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 12, April 2010, Pages 3422–3428
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us