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Endothelial cell scaffolds generated by 3D direct writing of biodegradable polymer microfibers

Paper ID Volume ID Publish Year Pages File Format Full-Text
8162 579 2011 8 PDF Available
Title
Endothelial cell scaffolds generated by 3D direct writing of biodegradable polymer microfibers
Abstract

The engineering of large (thickness > 100 μm) tissues requires a microvascular network to supply nutrients and remove waste. To produce microvasculature in vitro, a scaffold is required to mechanically support and stimulate endothelial cell (EC) adhesion and growth. Scaffolds for ECs are currently produced by patterning polymers or other biomaterials into configurations which often possess isotropic morphologies such as porous films and fibrous mats. We propose a new “direct-write” process for fabricating scaffolds composed of suspended polymer microfibers that are precisely oriented in 3D, providing directional architecture for selectively guiding cell growth along a desired pathway. The diameters of the fibers produced with this process were predictably and repeatably controlled through modulation of the system parameters, enabling production of fibers with microvascular-scale diameters (5–20 μm) from a variety of biodegradable polymers. These scaffolds were successfully seeded with ECs, which conformed to the geometry of the fibers and proliferated over the course of one week.

Keywords
Direct-write; Endothelial cell scaffold; Microfibers; Biodegradable materials; Tissue engineering
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Endothelial cell scaffolds generated by 3D direct writing of biodegradable polymer microfibers
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 7, March 2011, Pages 1872–1879
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us