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Mucosal irritation potential of polyelectrolyte multilayer capsules

Paper ID Volume ID Publish Year Pages File Format Full-Text
8172 579 1977 11 PDF Available
Title
Mucosal irritation potential of polyelectrolyte multilayer capsules
Abstract

Polyelectrolyte multilayer capsules have recently gained interest as carriers for drug delivery. When envisioning mucosal administration, one is focused with potential concerns such as tissue irritation and tissue damage, induced by the carrier itself. In this paper we demonstrate the use of a slug-based (Arion lusitanicus) assay to evaluate the mucosal irritation potential of different types of polyelectrolytes, their complexes and multilayer capsules. This assay allows to assess in a simple yet efficient way mucosal tissue irritation without using large numbers of vertebrates such as mice, rabbits or non-human primates. We found that although single polyelectrolyte components do induce tissue irritation, this response is dramatically reduced upon complexation with an oppositely charged polyelectrolyte, rendering fairly inert polyelectrolyte complexes. These findings put polyelectrolyte multilayer capsules further en route towards drug delivery applications.

Keywords
Mucosa; Microcapsule; Drug delivery; Heparin; Biocompatibility
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Mucosal irritation potential of polyelectrolyte multilayer capsules
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 7, March 2011, Pages 1967–1977
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us