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Human recombinant elastin-like protein coatings for muscle cell proliferation and differentiation

Paper ID Volume ID Publish Year Pages File Format Full-Text
834 67 2013 11 PDF Available
Title
Human recombinant elastin-like protein coatings for muscle cell proliferation and differentiation
Abstract

Recombinant proteins represent a new and promising class of polymeric materials in the field of biomaterials research. An important model for biomaterial design is elastin, the protein accounting for the elasticity of several tissues. Human elastin-like polypeptides (HELPs) have been developed as recombinant versions of elastin with the purpose of enhancing some peculiar characteristics of the native protein, like self-assembling. In this paper, we report on a comparative study of rat myoblasts response to coatings based on two different HELP macromolecules, with respect to control cultures on bare cell culture polystyrene and on a standard collagen coating. Cell behavior was analyzed in terms of adhesion, proliferation and differentiation. The collected data strongly suggest the use of HELPs as excellent biomaterials for tissue engineering and regenerative medicine applications.

Keywords
Human elastin-like polypeptides (HELPs); Recombinant proteins; Protein coatings; H9c2; Myoblast proliferation and differentiation
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Human recombinant elastin-like protein coatings for muscle cell proliferation and differentiation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 9, Issue 2, February 2013, Pages 5111–5121
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us