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Volume change of double cross-linked poly(aspartic acid) hydrogels induced by cleavage of one of the crosslinks

Paper ID Volume ID Publish Year Pages File Format Full-Text
835 67 2013 10 PDF Available
Title
Volume change of double cross-linked poly(aspartic acid) hydrogels induced by cleavage of one of the crosslinks
Abstract

In the present paper we report for the first time the development of redox-responsive biocompatible polymer gels. Double cross-linked poly(aspartic acid) hydrogels were prepared using two different cross-linking agents simultaneously. One of the cross-linkers was diaminobutane (DAB), the other cystamine (CYS). The relative amounts of DAB and CYS molecules were varied over a wide range while the total amount of cross-linker molecules (DAB + CYS) was kept constant. DAB provides stable cross-links, whereas CYS contains disulfide bonds, which can be broken by reduction. The cleavage of disulfide cross-links results in enhanced swelling and a significant decrease in the elastic modulus of the gels. These novel types of stimuli-responsive gels are promising candidates for new swelling controlled release matrices.

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Keywords
Double cross-linked gel; Polysuccinimide; Poly(aspartic acid); Hydrogels; Stimuli-responsive gels
First Page Preview
Volume change of double cross-linked poly(aspartic acid) hydrogels induced by cleavage of one of the crosslinks
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 9, Issue 2, February 2013, Pages 5122–5131
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering