fulltext.study @t Gmail

Surface morphology optimization for osseointegration of coated implants

Paper ID Volume ID Publish Year Pages File Format Full-Text
8364 587 2010 9 PDF Available
Title
Surface morphology optimization for osseointegration of coated implants
Abstract

This paper aims to establish a relationship between the surface morphology induced micromechanics and bone remodeling responses to a solid bead coated porous implant and further to develop a multiobjective optimization framework for the coating design of biomaterials. Multiscale modeling and remodeling techniques were developed, where a macroscopic analysis was initially performed to generate a global response to enable a microscopic analysis. The bone remodeling responses of the microscopic models (with a specific surface morphology) were evaluated in terms of the average apparent density developed in the peri-implant region. To explore the proposed multiscale analysis and design methods, a typical dental implantation setting is exemplified in this study. The response surface method (RSM) was utilized to relate the major implant coating parameters to the bone responses. It is found that increasing the volume fraction of the coating beads/particles results in a greater bone density, whereas increasing bead/particle size does not significantly affect the bone’s responses. Several different multiobjective optimization schemes were adopted to optimize the coated bead size and volume fraction, which reveal that the optimal design parameters of particle diameter and volume fraction are 100 μm – 35% and 38 μm – 17.5% for the cortical and cancellous bones respectively, agreeing with clinical data. To maximize the implant/bone interfacial stability, specific surface coating designs for particular locations are recommended.

Keywords
Implant topography; Surface coating; Bone remodeling; Osseointegration; Reponses surface method; Multiobjective optimization
First Page Preview
Surface morphology optimization for osseointegration of coated implants
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 27, September 2010, Pages 7196–7204
Authors
, , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us