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Biocompatibility of polymer grafted core/shell iron/carbon nanoparticles

Paper ID Volume ID Publish Year Pages File Format Full-Text
8370 588 2010 8 PDF Available
Title
Biocompatibility of polymer grafted core/shell iron/carbon nanoparticles
Abstract

For biomedical applications, emerging nanostructures requires stringent evaluations for their biocompatibility. Core/shell iron/carbon nanoparticles (Fe@CNPs) are nanomaterials that have potential applications in magnetic resonance imaging (MRI), magnetic hyperthermia and drug delivery. However, their interactions with biological systems are totally unknown. To evaluate their potential cellular perturbations and explore the relationships between their biocompatibility and surface chemistry, we synthesized polymer grafted Fe@CNPs with diverse chemistry modifications on surface and investigated their dynamic cellular responses, cell uptake, oxidative stress and their effects on cell apoptosis and cell cycle. The results show that biocompatibility of Fe@CNPs is both surface chemistry dependent and cell type specific. Except for the carboxyl modified Fe@CNPs, all other Fe@CNPs present low toxicity and can be used for further functionalization and in a wide range of biomedical applications.

Keywords
Nanomaterials; Core/shell nanoparticles; Biocompatibility; RT-CES; Cytotoxicity
First Page Preview
Biocompatibility of polymer grafted core/shell iron/carbon nanoparticles
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 19, July 2010, Pages 5083–5090
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering