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A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
8384 588 2010 10 PDF Available
Title
A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery
Abstract

Here we develop an injectable composite system based for repeated ultrasound-triggered on-demand drug delivery. An in situ-cross-linking hydrogel maintains model drug (dye)-containing liposomes in close proximity to gas-filled microbubbles that serve to enhance release events induced by ultrasound application. Dye release is tunable by varying the proportions of the liposomal and microbubble components, as well as the duration and intensity of the ultrasound pulses in vitro. Dye is minimal at baseline. The composite shows minimal cytotoxicity in vitro, and benign tissue reaction after subcutaneous injection in rats. Ultrasound application also triggers drug release for two weeks after injection in vivo.

Keywords
On-demand; Triggered-release; Ultrasound; Drug delivery; Hydrogels
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A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 19, July 2010, Pages 5208–5217
Authors
, , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us