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Polycaprolactone-based fused deposition modeled mesh for delivery of antibacterial agents to infected wounds

Paper ID Volume ID Publish Year Pages File Format Full-Text
8424 589 2011 9 PDF Available
Title
Polycaprolactone-based fused deposition modeled mesh for delivery of antibacterial agents to infected wounds
Abstract

Infections represent a significant source of site morbidity following tissue trauma. Scarring and tissue adhesion remain the challenging issues yet to be solved. Prolonged inflammation and morphology of the re-epithelisated layer are important considerations. We hypothesized that the solution lies not only in the biochemistry of biomaterial but also the micro-architecture of the scaffold used as the matrix for wound healing. Targeted delivery of antibiotics may provide an efficacious means of infection control through adequate release. Here, we study the use of 3-dimensional polycaprolactone–tricalcium phosphate (PCL–TCP) mesh for the delivery of gentamicin sulphate (GS) fabricated using a solvent-free method. PCL–TCP meshes incorporated with varying loads of GS were evaluated in vitro for elution profile, antimicrobial efficacy and cytotoxicity. Results showed that PCL–TCP meshes incorporated with 15wt% GS (PT15) efficiently eliminate bacteria within 2 h and demonstrate low cytotoxicity. Subsequently, PT15 meshes were evaluated using an infected full thickness wound mice model, and observed to eliminate bacteria in the wounds effectively. Additionally, mice from the PT15 treatment group (TG) showed no observable signs of overall infection through neutrophil count by day 7 and displayed efficient wound healing (94.2% wound area reduction) by day 14. Histology also showed significantly faster healing in TG through neo-collagen deposition and wound re-epithelisation. The meshes from TG were also observed to be expelled from wounds while gauze fibers from CG were integrated into wounds during healing.

Keywords
Polycaprolactone–tricalcium phosphate; Fused deposition modeling; Antibiotic delivery system; Infection control
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Polycaprolactone-based fused deposition modeled mesh for delivery of antibacterial agents to infected wounds
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 1, January 2011, Pages 279–287
Authors
, , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us