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The osteogenic effect of electrosprayed nanoscale collagen/calcium phosphate coatings on titanium

Paper ID Volume ID Publish Year Pages File Format Full-Text
8455 591 2010 9 PDF Available
Title
The osteogenic effect of electrosprayed nanoscale collagen/calcium phosphate coatings on titanium
Abstract

For orthopedic and dental implants, the ultimate goal is to obtain a life-long secure anchoring of the implant in the native surrounding bone. To this end, nanoscale calcium phosphate (CaP) and collagen-CaP (col-CaP) composite coatings have been successfully deposited using the electrospray deposition (ESD) technique. In order to study to what extent the thickness of these coatings can be reduced without losing coating osteogenic properties, we have characterized the mechanical and biological coating properties using tape tests (ASTM D-3359) and in vitro cell culture experiments, respectively. Co-deposition of collagen significantly improved coating adhesive and cohesive strength, resulting in a remarkably high coating retention of up to 97% for coating thicknesses below 100 nm. In vitro cell culture experiments showed that electrosprayed CaP and col-CaP composite coatings enhanced osteoblast differentiation, leading to improved mineral deposition. This effect was most pronounced upon co-deposition of collagen with CaP, and these coatings displayed osteogenic effects even for a coating thickness of below 100 nm.

Keywords
Calcium phosphate; Collagen; Nanocomposite; Biofilm
First Page Preview
The osteogenic effect of electrosprayed nanoscale collagen/calcium phosphate coatings on titanium
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 9, March 2010, Pages 2461–2469
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering