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An antimicrobial modified silicone peritoneal catheter with activity against both Gram positive and Gram negative bacteria

Paper ID Volume ID Publish Year Pages File Format Full-Text
8526 596 2009 7 PDF Available
Title
An antimicrobial modified silicone peritoneal catheter with activity against both Gram positive and Gram negative bacteria
Abstract

Peritonitis, exit site and tunnel infections are serious complications of peritoneal dialysis (CAPD), which may lead to catheter loss, despite measures taken to reduce the infection rate. Catheters coated with antimicrobials have shown only short-term activity. We have developed a process for conferring broad-spectrum, long-duration antimicrobial activity on CAPD catheters while reducing the risk of resistance. Catheters were processed using an impregnation method. Three agents were used: rifampicin, triclosan and trimethoprim. Tests included establishing the duration of activity before test bacteria became resistant, the ability to kill 100% of attached bacteria in a predetermined time (tK100), and ability to withstand multiple high-count challenges until failure in a flow model. Antimicrobial activity continued until it was stopped at 280 days and the agents prevented the emergence of resistant strains. tK100 results showed a >99.9% reduction of attached bacteria. The flow model showed no colonization when repeatedly challenged with high loads of meticillin-resistant Staphylococcus aureus or Escherichia coli for ∼90 days. The antimicrobial catheter material showed prolonged activity against common CAPD pathogens and promises to reduce clinical CAPD infection.

Keywords
Continuous ambulatory peritoneal dialysis (CAPD); Antimicrobial catheter; Rifampicin; Trimethoprim; Triclosan
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An antimicrobial modified silicone peritoneal catheter with activity against both Gram positive and Gram negative bacteria
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 18, June 2009, Pages 3167–3173
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us