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Self-assembled fluorescent magnetic nanoprobes for multimode-biomedical imaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
8550 597 2010 10 PDF Available
Title
Self-assembled fluorescent magnetic nanoprobes for multimode-biomedical imaging
Abstract

We fabricated multimode nanoprobes for acquisition of biological information at different object levels, i.e., in vivo detection and ex vivo validation for characterizing tumor angiogenesis. Fluorescent magnetic nanoprobes (FMNPs) were synthesized by using amphiphilic pyrenyl polyethylene glycol (Py-PEG) and superparamagnetic MnFe2O4 nanocrystals (MNCs). Py-PEG, which is synthesized by conjugation of hydrophilic PEG with hydrophobic and fluorescent 1-pyrenebutyric acid through an esterification process, is capable of self-assembly and maintaining a high UV fluorescent intensity in aqueous phase. Py-PEG can be used as a fluorescent surfactant that simultaneously and efficiently encapsulates MNCs to exhibit fluorescent and magnetic properties as well as maintaining high water-solubility. Consequently, we proved that our biologically non-toxic FMNPs were prominent multimode imaging probes by showing not only excellent MR sensitivity but also high illumination intensity with strong signal strength under short exposure time of UV light from the extensive imaging studies of in vitro/vivo and ex vivo using orthotopic and xenograft mice models.

Keywords
Nanoprobe; Magnetic resonance imaging; Multimode; Fluorescent
First Page Preview
Self-assembled fluorescent magnetic nanoprobes for multimode-biomedical imaging
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 35, December 2010, Pages 9310–9319
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering