fulltext.study @t Gmail

Evaluation of polymer matrices for an adsorptive approach to plasma detoxification

Paper ID Volume ID Publish Year Pages File Format Full-Text
8573 598 2010 9 PDF Available
Title
Evaluation of polymer matrices for an adsorptive approach to plasma detoxification
Abstract

Acute liver failure arises when potentially toxic metabolites accumulate in the bloodstream because of a breakdown in liver function. New extracorporeal systems combining membrane and adsorbent technologies are being developed to replace critical liver detoxification functions between diagnosis and transplantation. This study addresses the adsorption of representative plasma components on four different hydrophobic, polymeric adsorbents for possible use in an extracorporeal hemodialysis device. The adsorbents considered span a range of pore sizes and include both strongly hydrophobic divinylbenzene (DVB) matrices as well as a less hydrophobic acrylate matrix. Adsorption equilibrium and rate measurements were made for these matrices using human serum albumin (HSA), polyclonal human immunoglobulin G (IgG), and bilirubin (BR), as representative plasma components. Pore size was found to contribute significantly to selectivity. Results demonstrated that strongly hydrophobic materials with pore sizes that allow free access to protein-bound BR are most effective for BR removal whether they are initially clean or pre-saturated with HSA.

Keywords
Plasma proteins; Protein adsorption; Bilirubin; Hemodialysis; Liver Failure
First Page Preview
Evaluation of polymer matrices for an adsorptive approach to plasma detoxification
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 10, April 2010, Pages 2857–2865
Authors
, , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us